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I have seen that it is impossible to deprive a user manager of the site, the permission of a subfolder.
Are there any solutions for this?
Don't use manager for that. As you can imagine manager has all permissions on the site.
Please check in the official documentation for other alternatives. in short:
If none of them are useful for you, you can create a custom permission (check the official documentation, the part that start with "Now, sometimes these roles are not enough to set up the permissions we need").
I hope this info helps you!
Cheers.